Demonstrating the relationship of the basic theory of solid-phase extraction (SPE) to chromatography, this comprehensive reference illustrates how SPE techniques significantly contribute to the preparation of samples for a wide variety of analytical techniques. It provides step-by-step details on the applications of SPE to environmental matrices, broad-spectrum drug screening, veterinary drug abuse, pharmaceutical drug development, biological samples, and high-throughput screening. Written by world-renowned experts in the field, the book contains helpful reference charts, tables of solvent properties, selectivities, molecular acid/base properties, and more.